We are proud to share that “Lophine analogues as fluorophores for selective bioimaging of the endoplasmic reticulum” has been accepted for Chemical Communications as part of the themed collection: Chemistry for a Sustainable World – Celebrating Our Community Tackling Global Challenges.
The content: Fluorescent probes for endoplasmic reticulum (ER) labelling generally feature a well-established albeit limited group of structural motifs. We broadened the toolkit of ER-selective fluorophores with a set of new and synthetically accessible fluorescent lophine analogues. Unlike traditional ER-targeting dyes, the reported compounds achieve organelle specificity without requiring state-of-the-art moieties (sulfonamide or perfluorophenyl).
Our compounds can be synthesized in nothing but high-temperature water (HTW), feature low cytotoxicity, and demonstrate favorable photophysical properties for selective ER staining in live-cell imaging and higher-resolution imaging. Congratulations to all authors for this achievement!
